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Pharmacological dissociation of the b-wave and pattern electroretinogram

✍ Scribed by V. Porciatti; P. Bagnoli; R. Alesci; G. Fontanesi

Publisher: Springer-Verlag
Year: 1987
Tongue: English
Weight: 392 KB
Volume: 65
Category: Article
ISSN: 0012-4486
DOI: 10.1007/bf00149944

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✦ Synopsis

Electroretinographic responses to modulation of either luminance (focal ERG) or spatial contrast (pattern ERG) were recorded from the pigeon eye before and after intravitreal injection of glutamate analogues DL~ amino adipic acid (DL~ AA) and 2-amino-4 phosphonobutyric acid (APB). Both toxins reversibly abolished the b-wave. The pattern ERG was still present, however, when the b-wave had been abolished by the toxins. This result demonstrates that the b-wave and the pattern ERG can be pharmacologically dissociated and suggests the possibility that in pigeons the b-wave and pattern ERG reflect the activity of different generators.

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