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Scorpion toxins that block T-type Ca2+ channels in spermatogenic cells inhibit the sperm acrosome reaction

✍ Scribed by Ignacio López-González; Timoteo Olamendi-Portugal; José L De La Vega-Beltrán; Jurg Van der Walt; Karin Dyason; Lourival D Possani; Ricardo Felix; Alberto Darszon

Book ID: 117053072
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 252 KB
Volume: 300
Category: Article
ISSN: 0006-291X
DOI: 10.1016/s0006-291x(02)02859-0

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The direct electrophysiological characterization of sperm Ca 2ϩ channels has been precluded by their small size and flat shape. An alternative to study these channels is to use spermatogenic cells, the progenitors of sperm, which are larger and easier to patch-clamp. In mouse and rat, the only volta