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Scope of the radical addition–cyclization–elimination reaction of oxime ether towards the synthesis of tricyclic lactam derivatives

✍ Scribed by Habibur Rahaman; Atsushi Shirai; Okiko Miyata; Takeaki Naito

Book ID
104095657
Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
193 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of tricyclic lactam building blocks by the radical addition-cyclization-elimination (RACE) reaction is presented. A range of oxime ethers carrying unsaturated ester part have been tested for the radical reaction. A variety of substituents were incorporated around the aromatic backbones and their effect on the RACE reaction has been examined. In addition, the power of RACE reaction is demonstrated by preparation of a key intermediate for the synthesis of constrained analogue of methoctramine.

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