Scope of a Novel Three-Component Synthesis of Highly Functionalized Pyridines†
✍ Scribed by Dash, Jyotirmayee; Lechel, Tilman; Reissig, Hans-Ulrich
- Book ID
- 111978642
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 78 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1523-7060
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## Abstract magnified image 1,8‐Diazabicyclo[5.4.0]undec‐7‐ene (DBU) efficiently catalyzes three‐component one‐pot condensations of aldehyde, malononitrile, and thiophenol to produce highly functionalized pyridines in excellent yield in aqueous ethanol. J. Heterocyclic Chem., **46**, 69 (2009).
We report the development of a novel three-component coupling reaction (3CC) for the synthesis of alkoxy tetrahydropyridopyrimidines. Systematic optimization of reaction parameters identified 3CC conditions tolerant of a wide array of functionality at all three sites of diversity, providing densely