Sclerosing Rhabdomyosarcomas in Children and Adolescents: A Clinicopathologic Review of 13 Cases From the Intergroup Rhabdomyosarcoma Study Group and Children’s Oncology Group
✍ Scribed by Melissa C. Chiles; David M. Parham; Stephen J. Qualman; Lisa A. Teot; Julia A. Bridge; Fred Ullrich; Frederic G. Barr; William H. Meyer
- Book ID
- 106249619
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 523 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1093-5266
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Congenital anomalies were identified in 37 of 115 (32%) children and adolescents autopsied with rhabdomyosarcoma. An analysis of sex, age, site, and histology of cases with or without congenital anomalies showed no significant differences. Of the 45 identified anomalies, 14 were considered major and
## Abstract ## Background The cure rate for children/adolescents with localized rhabdomyosarcoma (RMS) has tripled over the past 25 years, but patients with metastatic disease at presentation have not benefited similarly, and urgently need new therapy. We evaluated a new drug pair, ifosfamide + do