Schizophrenia: Gender, family risk, and plasma homovanillic acid
✍ Scribed by Dávila, Ricardo ;Zumárraga, Mercedes ;González-Torres, Miguel A. ;Andía, Isabel ;Zamalloa, Maria I. ;Basterreche, Edurne ;Guimón, José ;Friedhoff, Arnold J.
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 323 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0148-7299
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✦ Synopsis
Plasma homovanillic acid concentration was assessed in 60 young schizophrenic patients, with and without first-degree relatives with schizophrenia, before treatment, and 3 days after starting haloperidol treatment. The baseline concentration of homovanillic acid in plasma was no different in the two groups before treatment; it was, however, significantly higher in the patients with relatives than in those without relatives diagnosed of schizophrenia after 3 days of haloperidol treatment.
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A method for simultaneous quantification of plasma homovanillic acid and 5-hydroxyindoleacetic acid has been developed, permitting more efficient neurochemical examinations of these often interrelated biogenic amine systems. Zinc sulphate and sodium hydroxide solutions were used for precipitating th