Schedule for Poster Presentations; Abstr
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Article
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2003
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Wiley (John Wiley & Sons)
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English
โ 435 KB
We report a general approach to the synthesis of Boc-protected 4-alkylprolines via asymmetric hydrogenation reactions. Starting from trans-4-hydroxyproline, the key unsaturated intermediates were obtained by Wittig-type reactions at the 4 position. The Crabtree catalyst (Ir[COD]PyPCy 3 PF 6 ) proved