✦ LIBER ✦

Schedule for Poster Presentations; Abstracts of Poster Section A; Abstracts of Poster Section B

Publisher: Wiley (John Wiley & Sons)
Year: 2003
Tongue: English
Weight: 435 KB
Volume: 71
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.10455

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✦ Synopsis

We report a general approach to the synthesis of Boc-protected 4-alkylprolines via asymmetric hydrogenation reactions. Starting from trans-4-hydroxyproline, the key unsaturated intermediates were obtained by Wittig-type reactions at the 4 position. The Crabtree catalyst (Ir[COD]PyPCy 3 PF 6 ) proved to be effective in the diastereoselective reduction of exocyclic olefins to give trans-substituted pyrrolidines. Good facial selectivities were also observed in heterogeneous hydrogenations with Raney-Ni to yield cis-substituted pyrrolidines. The incorporation of substituted prolines and prolinols obtained by this strategy into biologically relevant peptidomimetics will be discussed.

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Abstracts of Poster Section C; Abstracts

Abstracts of Poster Section C; Abstracts of Poster Section D; Abstracts of Poster Section E

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Abstracts of Poster Section B

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📂 Article 📅 2005 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 450 KB

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This study was conducted to gain insight into the factors that may be responsible for poorly differentiated aggressive tumors. ## BACKGROUND. Several recent reports have shown that the breast carcinoma mortality rate is approximately three times as high in African-American women compared with othe