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Schedule-dependent cytotoxicity of 5-fluorouracil and irinotecan in a colon cancer cell line

✍ Scribed by Yasuhiro Inoue; Chikao Miki; Hideki Watanabe; Junichiro Hiro; Yuji Toiyama; Eiki Ojima; Hidenori Yanagi; Masato Kusunoki


Book ID
106180026
Publisher
Springer Japan
Year
2007
Tongue
English
Weight
341 KB
Volume
41
Category
Article
ISSN
0944-1174

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Because of conflicting reports of clinical synergy, we used the tetrazolium-based colorimetric (MTT) assay to test in vitro combination effects of methotrexate (MTX) plus 5fluorouracil (FUra) in 4 schedules on 2 human non-small-cell lung cancer cell lines (adenocarcinoma, NCLH23; bronchioalveolar-ce

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✍ Bart Schuurman; Igor Sirovich; Gijsbert Heuff; Clasina L. Der Van Wilt; Godefrin πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 511 KB

## Abstract The mode of action of the combination treatment 5‐fluorouracil (5‐FU) and levamisole in colorectal cancer patients is unknown. It is postulated that the beneficial effect may be explained by an immunomodulatory effect on Kupffer cell (KC) cytotoxicity. We evaluated the effect of levamis