The folding of randomly coiled poly(bg1utamic acid) to the helical state has been studied in N-methylacetamide by titration methods. Since this solvent would be expected to form amide-peptide group hydrogen bonds with the unfolded form of the polymer, to a first approximation no helix stabilization
Scattering functions of poly(amino acid) in helix-coil transition
✍ Scribed by Y Ishimuro; H Hayashi; F Hamada; A Nakajima
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 378 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0032-3861
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## Abstract A polarimetric electric‐field‐jump relaxation apparatus is described and used to determine the relaxation spectrum for the helix–coil transition of poly(α,L‐glutamic acid) in water at 24°C. A maximum relaxation time of 1.7 μc occurs at the transition midpoint (pH = 5.9) yielding a rate
Potentiometric titrations and some complementary optical rotation data are presented for solutions of poly(L-glntamic acid) (PGA) in several H,O-ethanol mixtnres. The data allow the determination of the intrinsic p K (pKo), slope of the apparent pK (pKaPp), versus degree of ionization curves and of
The helix-coil transit.iotis for poly(L-glutamic acid) (PGA) in 0.2M NaCl and ill its mixture with dioxane were studied by the methods of spectropolarimetry, viscometry, and potentiometric titration at different temperatures from 8 to 50°C. The enthalpy and entropy differences between the helical an