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Scaling-up of a lactose wet granulation process in Mi-Pro high shear mixers

โœ Scribed by Dieter Ameye; Eseldin Keleb; Chris Vervaet; Jean Paul Remon; Erwin Adams; Desire L Massart


Book ID
114302102
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
242 KB
Volume
17
Category
Article
ISSN
0928-0987

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Aplaviroc 200 mg tablets were made by a high shear wet granulation process. A formulation and process DOE were carried out to define formulation and process parameters at pilot scale in GSKs R&D facility. During the scale up, several batches made at the production facility dissolved slower than the