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Scalarane Sesterterpenes from the Chinese Sponge Phyllospongia foliascens

✍ Scribed by Hong-Jun Zhang; Hai-Feng Tang; Yang-Hua Yi; Hou-Wen Lin

Publisher: John Wiley and Sons
Year: 2009
Tongue: German
Weight: 162 KB
Volume: 92
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200800377

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✦ Synopsis

Abstract

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Three new scalarane sesterterpenes, phyllofolactone L (1), phyllofenone D (2) and phyllofenone E (3), were isolated from the acetone extract of the South China Sea sponge Phyllospongia foliascens. Their structures were elucidated on the basis of spectroscopic analysis. Phyllofenone D (2) was cytotoxic against the P388 leukemia cell line with an IC~50~ value of 6.5 μg/ml.

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