New Sesterterpenoids from the Marine Sponge Phyllospongia papyracea

✍ Scribed by Wen-Jian Lan; Hou-Jin Li

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: German
• Weight: 68 KB
• Volume: 90
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200790121

✦ Synopsis

Abstract

Chemical investigation of an extract of the marine sponge Phyllospongia papyracea, collected from the South China Sea, led to the isolation and identification of three new scalarane‐type sesterterpenoids, compounds 1–3. Their structures were elucidated by spectroscopic methods, including 1D‐ and 2D‐NMR as well as high‐resolution ESI‐MS experiments. (12__α__,16__β__)‐12‐Acetoxy‐16‐hydroxy‐20,24‐dimethyl‐25‐norscalar‐17‐en‐24‐one (1) was cytotoxic against the leukemia P388 cancer cell line, with an IC~50~ value of 5 μg/ml.