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SB-656104-A: A Novel 5-HT7 Receptor Antagonist with Improved in vivo Properties.

✍ Scribed by Ian T. Forbes; et al. et al.


Publisher
John Wiley and Sons
Year
2003
Weight
96 KB
Volume
34
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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✍ Peter Eisenberg; Jazmin Figueroa-Vadillo; Rosalio Zamora; Veena Charu; Julio Haj πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 174 KB

## Background: Palonosetron, a highly selective and potent 5-ht(3) receptor antagonist with a strong binding affinity and a long plasma elimination half-life (approximately 40 hours), has shown efficacy in phase ii trials in preventing chemotherapy-induced nausea and vomiting (cinv) resulting from