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(+)-Saxitoxin: A First and Second Generation Stereoselective Synthesis

✍ Scribed by Fleming, James J.; McReynolds, Matthew D.; Du Bois, J.


Book ID
118222574
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
634 KB
Volume
129
Category
Article
ISSN
0002-7863

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The first total synthesis of Goniothalesdiol A, isolated from the stems of Goniothalamus amuyon (Annonaceae) is reported. The C2 stereocentre and C3/C4 syn diol were created by a Sharpless kinetic resolution followed by acetonide formation. The tetrahydropyran ring was formed and the C6 stereocentre