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Saussurea lappa induce apoptosis in HL-60 cells via activation of JNK and inhibition of ERK1/2

✍ Scribed by Kang, Su Jin; Ku, Sae Kwang; Lee, Young Joon

Book ID
122420262
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
79 KB
Volume
221
Category
Article
ISSN
0378-4274

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## Abstract Transcriptional activation of AP‐1 is intricately involved in cell proliferation and transformation. The natural product, nordihydroguaiaretic acid (NDGA) shows an inhibitory effect on the binding of jun/AP‐1 protein to the AP‐1 site in 12‐__O__‐tetradecanoylphorbol‐13‐acetate (TPA)‐sti