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Sarin Causes Altered Time Course of mRNA Expression of Alpha Tubulin in the Central Nervous System of Rats

✍ Scribed by Tirupapuliyur V. Damodaran; Alicia A. Mecklai; Mohamed B. Abou-Donia

Book ID
110331871
Publisher
Springer
Year
2002
Tongue
English
Weight
88 KB
Volume
27
Category
Article
ISSN
0364-3190

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## Abstract A time‐course study was carried out to measure the acetylcholinesterase (AChE) gene expression in the brain of female rats exposed to different doses of sarin and physostigmine. Short‐term effects were studied with an acute single subcutaneous dose (s.c.) of 80Β Β΅gΒ kg^βˆ’1^ (0.5 Γ— LD~50~)