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Sarin (nerve agent GB)-induced differential expression of mRNA coding for the acetylcholinesterase gene in the rat central nervous system

✍ Scribed by Tirupapuliyur V. Damodaran; Katherine H. Jones; Anand G. Patel; Mohamed B. Abou-Donia


Book ID
113993503
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
284 KB
Volume
65
Category
Article
ISSN
0006-2952

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## Abstract A time‐course study was carried out to measure the acetylcholinesterase (AChE) gene expression in the brain of female rats exposed to different doses of sarin and physostigmine. Short‐term effects were studied with an acute single subcutaneous dose (s.c.) of 80 µg kg^−1^ (0.5 × LD~50~)