Sampling the conformational space of membrane protein surfaces with the AFM
✍ Scribed by Simon Scheuring; Daniel J. Müller; Henning Stahlberg; Hans-Andreas Engel; Andreas Engel
- Book ID
- 105945884
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 348 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1432-1017
No coin nor oath required. For personal study only.
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Thermodynamically, intrinsic membrane proteins are stably anchored to the lipid bilayer but little information is available, however, as to the mechanical firmness of their rooting to the cell membrane. We like to know, for example, how big a force should be applied to uproot them from the lipid bil
The conformational space of the 20-residue membrane-bound portion of melittin has been investigated extensively with the conformational space annealing (CSA) method and the ECEPP/3 (Empirical Conformational Energy Program for Peptides) algorithm. Starting from random conformations, the CSA method fi