Exploring the conformational space of membrane protein folds matching distance constraints
β Scribed by Jean-Loup Faulon; Ken Sale; Malin Young
- Book ID
- 111752166
- Publisher
- Cold Spring Harbor Laboratory Press
- Year
- 2003
- Tongue
- English
- Weight
- 182 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0961-8368
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## Abstract The dynamic behavior of monomeric Vpu~1β32~ from HIVβ1 in different lipid environments has been studied. The peptide shows highly flexible behavior during the simulations and easily adapts to changing lipid environments as it experiences when travelling through the Golgi apparatus. Prot
We describe an algorithm which enables us to search the conformational space of the side chains of a protein to identify the global minimum energy combination of side chain conformations as well as all other conformations within a specified energy cutoff of the global energy minimum. The program is