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Sample-to-sample fluctuations in heterogeneous DNA

✍ Scribed by Zh. S. Gevorkian; Mai Suan Li; Chin-Kun Hu

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 303 KB
Volume: 48
Category: Article
ISSN: 0887-6266
DOI: 10.1002/polb.22142

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✦ Synopsis

Abstract

We studied the structure of heterogenous DNA in the native state. There are two different regimes in the sample‐to‐sample fluctuations of the free energy in the native state, which can be interpreted via the concept of local free energy of base pairs. In the first low‐temperature frozen regime, local free energies are random and there are large sample‐to‐sample fluctuations for short DNAs. In the high‐temperature molten regime, the weakly bounded base pairs are opened and do not give random contribution to the free energy of native DNA. As a result, sample‐to‐sample fluctuations are suppressed in the molten regime. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2010

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