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Sample size required for predefined linkage decision quality

✍ Scribed by Emil Kh. Ginsburg; Tatiana I. Axenovich

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 101 KB
Volume: 14
Category: Article
ISSN: 0741-0395
DOI: 10.1002/(sici)1098-2272(1997)14:5<479::aid-gepi3>3.0.co;2-x

No coin nor oath required. For personal study only.

✦ Synopsis

A method for estimating the sample size required to attain a predefined linkage decision quality (type I and type II errors) is proposed using the linkage test power estimate developed by Ginsburg et al. [(1996) Genet Epidemiol 13:355-366]. The method is applicable for samples of arbitrarily structured pedigrees collected via proband. Comparison of different ascertainment schemes and pedigree structures by their consequent minimal sample size was performed. For recessive and dominant inheritance with complete penetrance, the relative ranks of the ascertainment schemes are invariant regardless of the true recombination fraction value and the trait and marker gene frequencies, which enables one to point out the better scheme. The feasibility of evaluating a sampling strategy by the cost of pedigree collection is also considered, and comparison between these two methods of sample planning is performed. Genet. Epidemiol. 14:479-491, 1997.

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