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On the relative sample size required for multiple comparisons

✍ Scribed by John S. Witte; Robert C. Elston; Lon R. Cardon

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 61 KB
Volume: 19
Category: Article
ISSN: 0277-6715
DOI: 10.1002/(sici)1097-0258(20000215)19:3<369::aid-sim335>3.0.co;2-n

No coin nor oath required. For personal study only.

✦ Synopsis

Multiple comparisons are commonly made in epidemiologic and genetic research. How to appropriately adjust for multiple comparisons remains a controversial issue. This note demonstrates, however, that large increases in the number of comparisons has a limited e!ect on the sample size required to maintain an experimentwise -level. In particular, the relative sample size required increases only linearly with the logarithm of the number of comparisons made.

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