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Sample size correction for treatment crossovers in randomized clinical trials with a survival endpoint

✍ Scribed by Raphaël Porcher; Vincent Lévy; Sylvie Chevret

Book ID
114186964
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
157 KB
Volume
23
Category
Article
ISSN
0197-2456

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This paper presents a sample size formula for testing the equality of k (\*2) survival distributions using the Tarone-Ware class of test statistics in the presence of non-proportional hazards, time dependent losses, non-compliance and drop-in. This method extends the derivation by Lakatos of a sampl