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salvador Promotes Both Cell Cycle Exit and Apoptosis in Drosophila and Is Mutated in Human Cancer Cell Lines

✍ Scribed by Nicolas Tapon; Kieran F. Harvey; Daphne W. Bell; Doke C.R. Wahrer; Taryn A. Schiripo; Daniel A. Haber; Iswar K. Hariharan

Book ID
117269204
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
815 KB
Volume
110
Category
Article
ISSN
0092-8674

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## Abstract Mycophenolic acid (MPA) specifically inhibits inosine‐5′‐monophosphate dehydrogenase, the first committed step toward GMP biosynthesis. In its morpholinoethyl ester pro‐drug form it is one of the most promising immunosuppressive drugs recently developed. The aim of the present study was