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salmonella typhimurium (ta100) mutagenicity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone and its open- and closed-ring analogs

✍ Scribed by Robert T. Lalonde; Gary P. Cook; Hannu Perakyla; Carlton W. Dence; John G. Babish; J. H. Carver


Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
818 KB
Volume
17
Category
Article
ISSN
0893-6692

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The chlorinated drinking water mutagen 3-chloro-4-methyl-5-hydroxy-2(5H)-furanone (MCF) occurs at concentrations similar to or greater than that of the related furanone 3-chloro-4-(dichloromethyl)-5hydroxy-2(5H)-furanone (MX). MCF and MX differ structurally only by replacement of a 3-methyl in MCF w

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## Abstract 3‐Chloro‐4‐(dichloromethyl)‐5‐hydroxy‐2(5__H__)‐furanone (MX) is a genotoxic chlorination by‐product in drinking water. There is some evidence that it has developmental toxic effects in vitro but its potential to cause developmental effects in vivo is not known. The developmental effect