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Salivary Acetaldehyde Concentration According to Alcoholic Beverage Consumed and Aldehyde Dehydrogenase-2 Genotype

✍ Scribed by Akira Yokoyama; Eri Tsutsumi; Hiromi Imazeki; Yoshihide Suwa; Chizu Nakamura; Takeshi Mizukami; Tetsuji Yokoyama


Book ID
109124116
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
259 KB
Volume
32
Category
Article
ISSN
0145-6008

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## Abstract The less‐active homozygous alcohol dehydrogenase‐1B (__ADH1B\*1/\*1__) and inactive heterozygous aldehyde dehydrogenase‐2 (__ALDH2\*1/\*2__) increase the risk of upper aerodigestive tract cancer (UADTC) in Japanese alcoholics. We evaluated associations between ADH1B/ALDH2 genotypes and

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In this study, 1,000 Japanese male alcoholics were consecutively screened by upper gastrointestinal endoscopy with esophageal iodine staining. Associations among cancer-detection rates, drinking and smoking habits, and aldehyde dehydrogenase-2 (ALDH2) genotypes were evaluated. A total of 53 patients