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Saikosaponin-d increases the radiosensitivity of smmc-7721 hepatocellular carcinoma cells by adjusting the g0/g1 and g2/m checkpoints of the cell cycle

✍ Scribed by Bao-Feng Wang,Zhi-Jun Dai,Xi-Jing Wang…


Book ID
121613876
Publisher
BioMed Central
Year
2013
Tongue
English
Weight
730 KB
Volume
13
Category
Article
ISSN
1472-6882

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## Abstract Lithium, a therapeutic agent for bipolar disorder, can induce G2/M arrest in various cells, but the mechanism is unclear. In this article, we demonstrated that lithium arrested hepatocellular carcinoma cell SMMC‐7721 at G2/M checkpoint by inducing the phosphorylation of cdc2 (Tyr‐15). T