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SAHA Inhibits the Growth of Colon Tumors by Decreasing Histone Deacetylase and the Expression of Cyclin D1 and Survivin

✍ Scribed by Jong-Shiaw Jin, Tang-Yi Tsao, Pei-Chang Sun, Cheng-Ping Yu, Ching Tzao


Book ID
113100519
Publisher
Springer Netherlands
Year
2012
Tongue
English
Weight
546 KB
Volume
18
Category
Article
ISSN
1219-4956

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## Abstract Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by histone deacetylase (HDAC). HDAC inhibitors can block cancer cell growth by restoring expression of tumor suppressor genes. In th