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PPARГ and RXR synergistically inhibit the expression of cyclin D1 and suppress the growth of pancreatic cancer cells

✍ Scribed by Miyuki Toyota; Yoshiji Miyazaki; Shinji Kitamura; Yutaka Nagasawa; Shintaro Hiraoka; Tatsuya Kiyohara; Yasuhisa Shinomura; Yuji Matsuzawa


Book ID
119424401
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
176 KB
Volume
118
Category
Article
ISSN
0016-5085

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Peroxisome proliferator-activated receptor ␥ (PPAR␥) inhibits the growth of several types of cancer cells. However, the mechanisms by which this occurs are poorly understood. The goal of the present study was to investigate the effects of PPAR␥ on mutated ras-induced cell growth, activation of trans