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Safety of methotrexate for inflammatory bowel disease

✍ Scribed by Ricardo Moreno-Otero; Luisa García-Buey; María Trapero-Marugán

Book ID
119230112
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
107 KB
Volume
44
Category
Article
ISSN
1590-8658

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In animal models, the antiinflammatory mechanism of action of methotrexate has been attributed to elevation of the extracellular concentration of the endogenous autocoid, adenosine. Our goal was to determine if methotrexate elevates adenosine concentrations in plasma and at the site of disease in pa