Low-dose oral methotrexate in refractory inflammatory bowel disease
โ Scribed by Todd H. Baron; Christopher D. Truss; Charles O. Elson
- Book ID
- 112508936
- Publisher
- Springer US
- Year
- 1993
- Tongue
- English
- Weight
- 575 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0163-2116
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๐ SIMILAR VOLUMES
## Background: This study aimed to evaluate the efficacy of oral tacrolimus in patients with inflammatory bowel disease (ibd) refractory to conventional therapy, including azathioprine, 6-mercaptopurine, and infliximab. ## Methods: Retrospective review of all patients with ibd treated with oral t
In animal models, the antiinflammatory mechanism of action of methotrexate has been attributed to elevation of the extracellular concentration of the endogenous autocoid, adenosine. Our goal was to determine if methotrexate elevates adenosine concentrations in plasma and at the site of disease in pa