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Safety and efficacy of live attenuated, cold-adapted, influenza vaccine-trivalent

โœ Scribed by Belshe, Robert B; Mendelman, Paul M


Book ID
122682394
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
357 KB
Volume
23
Category
Article
ISSN
0889-8561

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A procedure to attenuate live influenza virus of type A and type B was developed using adaptation of the virus to grow at 25 degrees C (cold adaptation; ca). Through a series of stepwise passages, two stable mutants were obtained and designated as 'Master' strains, one for type A influenza virus (A/