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Efficacy and effectiveness of attenuated, cold-adapted, trivalent intranasal influenza vaccine

✍ Scribed by Robert B Belshe

Book ID: 117549647
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 98 KB
Volume: 1219
Category: Article
ISSN: 0531-5131
DOI: 10.1016/s0531-5131(01)00393-4

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A procedure to attenuate live influenza virus of type A and type B was developed using adaptation of the virus to grow at 25 degrees C (cold adaptation; ca). Through a series of stepwise passages, two stable mutants were obtained and designated as 'Master' strains, one for type A influenza virus (A/