Safe disposal of inflammatory monosodium urate monohydrate crystals by differentiated macrophages
โ Scribed by R. Clive Landis; Darshna R. Yagnik; Oliver Florey; Pandelis Philippidis; Vivien Emons; Justin C. Mason; Dorian O. Haskard
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 339 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective It has previously been shown that as monocytes differentiate into macrophages, they lose the ability to secrete proinflammatory cytokines in response to monosodium urate monohydrate (MSU) crystals. The purpose of this study was to investigate whether MSU crystals induce ma
## Abstract ## Objective To determine whether infiltrating monocytes, neutrophils, or resident macrophages contribute to the early inflammatory response to monosodium urate monohydrate (MSU) crystals in vivo. ## Methods MSU crystalโinduced inflammation was monitored using a peritoneal model of a