Monosodium urate monohydrate crystal–recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout

Resident macrophages initiating and driv

Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal–induced murine peritoneal model of acute gout

✍ William John Martin; Michaela Walton; Jacquie Harper 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 350 KB 👁 1 views

## Abstract ## Objective To determine whether infiltrating monocytes, neutrophils, or resident macrophages contribute to the early inflammatory response to monosodium urate monohydrate (MSU) crystals in vivo. ## Methods MSU crystal–induced inflammation was monitored using a peritoneal model of a