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SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models

โœ Scribed by Ono, Yoko; Tanaka, Hirotaka; Takata, Masafumi; Nagahara, Yuki; Noda, Yasuhiro; Tsuruma, Kazuhiro; Shimazawa, Masamitsu; Hozumi, Isao; Hara, Hideaki


Book ID
121688678
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
1016 KB
Volume
559
Category
Article
ISSN
0304-3940

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Acute and chronic administration of the
โœ Yoshio Minabe; Kiyoshi Matsuno; Charles R. Ashby Jr. ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 141 KB ๐Ÿ‘ 1 views

In this study, we examined the effect of the acute and repeated administration of the selective sigma () 1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (SA4503) on the number and firing pattern of spontaneously active dopamine (DA) neurons in substantia ni