Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis

Glutamate AMPA receptors change in motor

Glutamate AMPA receptors change in motor neurons of SOD1G93A transgenic mice and their inhibition by a noncompetitive antagonist ameliorates the progression of amytrophic lateral sclerosis-like disease

✍ Massimo Tortarolo; Giuliano Grignaschi; Novella Calvaresi; Eleonora Zennaro; Gab 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 550 KB

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder involving the selective degeneration of motor neurons. In a small proportion of patients, ALS is caused by mutations in copper/zinc superoxide dismutase (SOD1), and mice overexpressing SOD1 G93A mutant develop a syndrome that close