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Sa1231 Elevated Serum IL-17 Levels in Crohn's Disease Correlate With Disease Activity but Do Not Predict Response to Infliximab

✍ Scribed by Abhyankar, Anita; Ham, Maggie; Bai, Aiping; Cheifetz, Adam S.; Robson, Simon C.; Moss, Alan C.

Book ID: 122143004
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 222 KB
Volume: 146
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(14)60835-0

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## Background: We analyzed the influence of Crohn's disease (CD)associated IL23R gene variants on IL-22 that is expressed in IL-23Rϩ Th17 cells. Methods: IL-22 serum levels were measured in 242 CD patients and in 31 healthy controls. Subanalyses included serum levels of IL-6, TNF-␣, IL-17A, IL-17