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S2042 CD8+ T Cell Infiltration and Decreased FOXP3+ Regulatory T Cell Numbers in the Primary Tumor Predict for Survival in Gastric Cancer Patients

โœ Scribed by Lee, Victoria S.; Lim, Kiat-Hon; Ling, Khoon-Lin


Book ID
122862743
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
74 KB
Volume
134
Category
Article
ISSN
0016-5085

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High frequency of tumor-infiltrating FOX
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Regulatory T cells (T reg ) inhibit the generation of host-versus-tumor immunity via suppression of tumor-specific effector T-cell responses and development of immune tolerance to neoplastic cells. The transcription factor forkhead box P3 (FOXP3) is an intracellular key molecule for T reg developmen