S11. C-erbB-2 overexpression and amplification in uterine sarcomas
- Book ID
- 119233432
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 33 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1359-6349
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The c-erbB-2 oncogene has been extensively studied in mammary carcinomas since Slamon and colleagues demonstrated the association between amplification and poor prognosis in 1987. Further work found that amplification was accompanied by overexpression of the protein; however, this relationship is no
The aim of this study is to address the role of mdm-2-gene amplification in the tumorigenesis of uterine sarcomas. Differential PCR with DNA from formalin-fixed paraffin-embedded specimens was employed in 12 patients with uterine sarcomas. We detected mdm-2-gene amplification in 4 out of 12 uterine
## Abstract ## BACKGROUND Overexpression of the epidermal growth factor type II receptor HERβ2/__neu__ has been associated with resistance to chemotherapy and poor survival in several human tumors. In the current study, the authors have determined the frequency and clinical significance of HERβ2/_