Is there a relationship between c-erbB-1 and c-erbB-2 amplification and protein overexpression in NSCLC?
✍ Scribed by Meert, Anne-Pascale; Martin, Benoit; Verdebout, Jean-Marc; Noël, Sophie; Ninane, Vincent; Sculier, Jean-Paul
- Book ID
- 119319030
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 208 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0169-5002
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Amplification of the int-2 oncogene was measured in a series of breast tumours and related to amplification of the c-myc and c-erbB-2 oncogenes, histopathological features and relapse-free and overall survival. int-2 was amplified in I I%, c-myc in 20% and c-erbB-2 in 27% of the tumours assessed. in
Background. Amplification and/or overexpression of the C-erbB-2 gene has been demonstrated in breast and gastric cancer and is thought to be involved in the process of gastric cancer metastasis. Methods. The expression of C-erbB-2 protein in human gastric cancer was examined by immunohistochemistry