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(S)-2-chloro-2-fluoroethanoyl isocyanate, a chiral derivative of trichloroacetyl isocyanate

✍ Scribed by Petr Vodička; Ludvík Streinz; Bohumír Koutek; Miloš Buděšínský; Jan Ondrácek; Ivana Císařová


Book ID
102073800
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
120 KB
Volume
15
Category
Article
ISSN
0899-0042

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A convenient, high yield one-pot methodology for the synthesis of pharmaceutically interesting 3-unsubstituted-2,4-oxazolidinediones from a-hydroxyesters is described. A primary carbamate was generated in situ from the corresponding a-hydroxyester and trichloroacetyl isocyanate, then converted to th