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Réactions d'oximation de cétones III. Effets de structure dans la réaction d'addition neutre et acido-catalysée de l'hydroxylamine

✍ Scribed by G. Lamaty; A. Petitjean; J. P. Roque; A. Natat

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
514 KB
Volume
98
Category
Article
ISSN
0165-0513

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✦ Synopsis

Abstract

Rate constants for addition of hydroxylamine to a series of twenty‐four ketones have been measured, in water at 25,00 ± 0,02°C, for both acid‐catalyzed (k) and pH‐independent (k~o~) pathways. Structural effects seem to be operating in the same manner on k~o~ and k values, except in a few cases. Results are consistent with a “reactant‐like” transition state.

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✍ B. Boyer; G. Lamaty; C. Moreau 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 283 KB

In the present investigation, we have measured the secondary kinetic deuterium isotope effects in hydroxylamine addition reaction for a series of cyclohexanones, both hindered and unhindered. We observed a slightly direct isotope effect, __k__^H^__/k__^D^ > 1.00, for unhindered cyclohexanones and an