Réactions d'addition nucléophile sur les cétones dépendence conformationnelle de l'effet isotopique
✍ Scribed by B. Boyer; G. Lamaty
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 252 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0165-0513
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In the present investigation, we have measured the secondary kinetic deuterium isotope effects in hydroxylamine addition reaction for a series of cyclohexanones, both hindered and unhindered. We observed a slightly direct isotope effect, __k__^H^__/k__^D^ > 1.00, for unhindered cyclohexanones and an
## Abstract Rate constants for addition of hydroxylamine to a series of twenty‐four ketones have been measured, in water at 25,00 ± 0,02°C, for both acid‐catalyzed (k) and pH‐independent (k~o~) pathways. Structural effects seem to be operating in the same manner on k~o~ and k values, except in a fe