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Ryanodine-sensitive Ca2+ release mechanism of rat pancreatic acinar cells is modulated by calmodulin

✍ Scribed by Terutaka Ozawa

Book ID
117351223
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
362 KB
Volume
1452
Category
Article
ISSN
0167-4889

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Characterization of two different Ca2+up
Characterization of two different Ca2+uptake and IP3-sensitive Ca2+release mechanisms in microsomal Ca2+pools of rat pancreatic acinar cells
✍ T. Ozawa; F. ThΓ©venod; I. Schulz πŸ“‚ Article πŸ“… 1995 πŸ› Springer 🌐 English βš– 857 KB

We have examined the effect of the Ca2+ (Mg2+)-ATPase inhibitors thapsigargin (TG) and vanadate on ATP-dependent 45Ca2+ uptake into IP3-sensitive Ca2+ pools in isolated microsomes from rat pancreatic acinar cells. The inhibitory effect of TG was biphasic. About 40-50% of total Ca2+ uptake was inhibi