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Rx-Cre, a tool for inactivation of gene expression in the developing retina

✍ Scribed by Eric C. Swindell; Travis J. Bailey; Felix Loosli; Chaomei Liu; Felipe Amaya-Manzanares; Kathleen A. Mahon; Joachim Wittbrodt; Milan Jamrich

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 273 KB
Volume: 44
Category: Article
ISSN: 1526-954X
DOI: 10.1002/dvg.20225

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Rx is a homeobox‐containing gene that is critical for vertebrate eye development. Its expression domain delineates a field of cells from which the retina and the ventral hypothalamus develop. The 5′ upstream regulatory sequences of the medaka fish Rx gene are functionally conserved during evolution to a degree that they direct gene expression into the Rx‐expressing field of cells in mice. Using these sequences, we made a Cre line that can be used for inactivation of gene expression in the developing retina. genesis 44:361–363, 2006. Published 2006 Wiley‐Liss, Inc.

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