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Rutin in rat liver ischemia/reperfusion injury: Effect on DDAH/NOS pathway

✍ Scribed by Raffael Lanteri; Rosaria Acquaviva; Claudia Di Giacomo; Valeria Sorrenti; Giovanni Li Destri; Marco Santangelo; Luca Vanella; Antonio Di Cataldo

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
332 KB
Volume
27
Category
Article
ISSN
0738-1085

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✦ Synopsis

Abstract

Nitric oxide (NO) plays a key role in the relationship between microcirculatory disorders and I/R injuries. Our results demonstrated a significant modification in the hepatic function of I/R rats compared with the control group; treatment with rutin reported hepatic damage markers to control value. Levels of plasmatic and hepatic thiol groups decreased in the I/R untreated group, and this decrease was inhibited by rutin treatment. In addition, we observed an increase in the iNOS expression in I/R group compared with control and rutin administration attenuated this increase; in post‐ischemic reperfused rutin‐treated rats there was a significant increase in eNOS expression compared with the I/R untreated group. In the same experimental conditions an increase in DDAH 1 expression was observed in I/R group only; rutin treatment also counteracted this increased expression. These data suggest that rutin treatment could be useful for preventing oxidative damage associated with hepatic post‐ischemic reperfusion injury. © 2007 Wiley‐Liss, Inc. Microsurgery 2007.

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