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Protective effects of ligustrazine on ischemia-reperfusion injury in rat kidneys

✍ Scribed by Lijiang Sun; Yujun Li; Jingsen Shi; Xiao Wang; Xiang Wang

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
78 KB
Volume
22
Category
Article
ISSN
0738-1085

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✦ Synopsis

To investigate the protective effects of ligustrazine on renal ischemia-reperfusion injury, the influence of ligustrazine injection on plasma superoxide dismutase (SOD), malondialdehyde (MDA), and endothelin-1 (ET-1), as well as changes of morphology of renal tubules, were studied in rat kidney models with ischemia-reperfusion injury. The results showed that in the group treated with ligustrazine, the plasma SOD level was significantly higher than that of the control group (P < 0.05), but levels of plasma MDA and ET-1 and the pathological grading of injured renal tubules were significantly lower than those in the control group (P < 0.05). These findings suggest that ligustrazine has protective effects against ischemia-reperfusion injury in rat kidneys.

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