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Ruthenium-catalyzed synthesis of substituted 2-hydroxymorpholines and substituted morpholines

✍ Scribed by Wei-Yang Su; C.L. LeBas; Albert C. Kopecky; John F. Knifton


Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
193 KB
Volume
33
Category
Article
ISSN
0040-4039

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## Abstract The synthesis of morpholines and oxazepanes derivatives containing a trifluoromethyl group on a quaternary carbon has been achieved from a common enantiopure __O__‐allyl amino ether precursor. Classic 6‐__exo__ iodoamination provided the iodomorpholines, versatile synthetic intermediate